The endocannabinoid system is extremely complex!

The endocannabinoid system is extremely complex it consists of numerous G protein coupled receptors (CB receptors are included in this class) transient receptor potential channels and nuclear receptors. This is just a glimpse at how your diet plays a huge role in your health. Cut out the crap replace it with goodness! Phytocompounds found in all plants and fungi feed this system!

Aside from Cannabis numerous phytocompounds have shown affinity to CB receptors.
“Different widespread (canonical) triterpenoids have already been shown to inhibit metabolic enzymes of the major EC 2‐AG, ubiquitous plant flavonoids were found to inhibit FAAH, the metabolic enzyme degrading AEA and other N‐acylethanolamines (NAEs) and to weakly modulate CB receptors. Intriguingly, the ubiquitous plant sesquiterpene β‐caryophyllene (BCP) has been shown to exert potent CB2 receptor‐mediated cannabimimetic effects in mice and N‐alkylamides from maca (Lepidium meyenii Walp.) and black pepper (Piper nigrum L.) show cannabimimetic effects in vitro and in vivo respectively. The polyacetylene falcarinol (carotatoxin) present in carrots and other vegetables was shown to inhibit CB1 receptor activation by AEA in vitro. Several isoprenylated analogues of the naturally occurring plant stilbenoid trans‐resveratrol bind to both CB1 and CB2 receptors with low affinity. The widespread dietary triterpnoids oleanolic acid (present in olive oil) and ursolic acid have been shown to inhibit ABDH12, an enzyme that controls 2‐AG levels in immune cells. Thus, different dietary phytochemicals have already been shown to directly or indirectly modulate the ECS”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429335/…

Phytochemicals found in cinnamon, garlic, mustard, tumeric, horseradish, tobacco, mint, cannabis, cayenne pepper and oregano have been proven to react with transient receptor potential channels. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240255/

Phytochemicals found in ginseng, gingko biloba, cayenne pepper, sesame seeds, yin yang, grapes and oregano have shown affinity to nuclear receptors (PPARa and PPARy). https://www.sciencedirect.com/…/artic…/pii/S2211383517301624

Photo credit: https://profofpot.com/thc-cbd-cell-targets-receptors/

Endocannabinoid Awareness


Let’s cover some basics
1. Endocannabinoid system- the natural occurring system inside every skeletal animals that promotes healing. Every toxin can potentially throw this system off balance, creating chaos that creates chronic conditions.
2. 5 main functions of this system- pain sensation, cell function, appetite, mood and sleep. The body’s self regulator it has so many more functions then these!
3. Receptor locations- inside every system in the body inside and out. Also found in our chromosomes and genes.
4. Cannabinoids- 3 types: the body produces it’s own, plants based and synthetic.
5. Terpenes- Oils found in numerous plants that contribute to healing this system. Also what give each plant a unique smell.
6. Flavonoids- Flavonoids are a diverse group of phytonutrients (plant chemicals) found in almost all fruits and vegetables. Along with carotenoids, they are responsible for the vivid colors in fruits and vegetables. Flavonoids are the largest group of phytonutrients, with more than 6,000 types. Also play a unique role in healing this system.
7. Receptors- CB1, CB2, GPR55, TRPV1 and PPARy. Cannabis, Hemp and Liverwort are unique in that they hold compounds that our CB1 and CB2 receptors respond to as if they were the bodies natural endocannabinoids anandamide and 2-AG. GPR55, TRPV1 and PPARy respond to phytocannabinoids found in numerous plants, they also respond terpenes, flavonoids, amino acids, and proteins.
8. Homeostasis- achieving balance within the system. This is when healing takes place.
9. Entourage effect- using all cannabinoids, terpenes and flavonoids plants have to offer to produce unique chemical reactions within the Endocannabinoid system.
10. Cannabis is unique in that it supplies certain compounds no other plants does. Each strain also produce numerous terpenes and flavonoids found in other plants. That’s why full spectrum products work best. You can incorporate numerous fruits, vegetables and spices in to your diet to achieve similar healing results.
11. Using cannabis in raw, heated and aged forms supplies different cannabinoids to this system.
12. When treating any chronic condition ingestion is best. Smoking has medical benefits especially to certain lung conditions (relaxes the tissues). Smoking Cannabis alone does not cause lung cancer! The National Cancer Institute admits this, they also admit it cures cancer. Who won’t allow the admission that this plant heals? The good old FDA. What cause lung cancer you might ask? Number 1 cause of cancer especially lung cancer an off balanced Endocannabinoid system!
13. The Endocannabinoid system regulates all the molecules within us (dopamine, serotonin, oxytocin, cortisol, insulin, GABA etc) Emotions can literally makes us sick if they are over or under produced.
14. Cannabis helps the body breakdown sugars

You can repair all cells within the body inside and out! Meaning you can regrow bone, cartilage, skin, hair, muscle, EVERYTHING!
I think this is it for now! Adding full spectrum products into your life will heal you so you can live your life as it was meant to be lived!

Gift orders should all be in on or before Tuesday December 17th.

Cannabis Medicine Online and The Church of the Holy Smoke have been experiencing delays in our shipping due to the high holiday volumes of air mail. We suggest completing all orders that may contain holiday gifts by Tuesday December 17h. Or earlier to ensure a timely delivery. As always CMO shipments go out within 24 hours of processing. We here at CMO and The Church of the Holy Smoke which I preside as US Bishop would like to wish you a very merry Christmas celebration and a Happy New Year!

$99 Ounces in time for Christmas!

Cannabis Medicine Online has just stocked the site with a $99.00 ounce of Gelato a hard hitting Indica strain. The bud is a small nug very dense and extremely stony! Get it while the supply lasts. We will do our best to keep a $99 ounce available until New Years! Happy Holidays from all of us at CMO!